Efficacy and acceptability of a mifepristone-misoprostol combined regimen for early induced abortion among women in Mexico City
Peña, M.; Dzuba, I.G.; Smith, P.S.; Mendoza, L.J.A.; Bousiéguez, M.; Martínez, M.ía.L.G.ía.; Polanco, R.R.ío.; Villalón, A.E.F.; Winikoff, B.
International Journal of Gynaecology and Obstetrics the Official Organ of the International Federation of Gynaecology and Obstetrics 127(1): 82-85
2014
ISSN/ISBN: 1879-3479 PMID: 24957534 DOI: 10.1016/j.ijgo.2014.04.012Document Number: 636612
To evaluate the experience of women receiving mifepristone-misoprostol for early induced abortion in public sector facilities in the Federal District of Mexico City. An open-label prospective study was conducted with 1000 pregnant women who sought induced abortion with a pregnancy of up to 63days of gestation, as measured from the date of their last menstrual period. The study was conducted in three public sector healthcare facilities: two secondary level hospitals and one primary care clinic. Women ingested 200mg mifepristone on day 1, followed by 800μg buccal misoprostol 24hours later, and they returned for follow-up on day 8. The primary outcome was complete abortion without recourse to surgical intervention. A total of 971 women received mifepristone-misoprostol and were included in the analysis for efficacy of treatment. The overall efficacy of the combined medical abortion regimen studied was 97.3% (n=945); the success rate did not vary significantly by gestational age (95.9%-100%; P=0.449). Most women (n=922, 95.0%) had a successful induced abortion with only one dose of misoprostol. The combined mifepristone and buccal misoprostol regimen was found to be highly effective and acceptable among Mexican women. www.ClinicalTrials.gov: NCT00386282.