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Molecular interaction between PrP protein and the signal protein 14-3-3 beta

Mei, G.-y.; Li, Y.; Wang, G.-r.; Zhang, B.-y.; Tian, C.; Chen, C.; Zhou, R.-m.; Wang, X.; Li, X.-l.; Wang, K.-x.; Han, J.; Dong, X.-p.

Bing du Xue Bao 25(3): 208-212

2009

ISSN/ISBN: 1000-8721
PMID: 19634764
Document Number: 636158
The molecular interaction between PrP and 14-3-3 beta and the possible interactional domain between two proteins were studied by co-immunoprecipitation, pull down and FRET assays. The results showed that PrP protein could interact with 14-3-3 beta in vitro and in vivo. The domain which responded for the interaction was located at C-terminal of PrP (amino acid residues 106 to 126). This study of the interaction between PrP and 14-3-3 protein further provided the insight into the potential role of 14-3-3 in the biological function of PrP and the pathogenesis of prion disease.

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