Influence of cortical neurotrophic factors on the neurocytokine production system in acute hemorrhagic stroke
Kul'chikov, A.E.; Kositsyn, N.S.; Svinov, M.M.; Vasil'eva, I.G.; Makarenko, A.N.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 3: 15-19
2009
ISSN/ISBN: 0031-2991 PMID: 19919011 Document Number: 636048
The mechanism of therapeutic action of cortical neurotropic factors (CNTF) was studied in hemorrhagic stroke. In intracerebral hemorrhage, CNTFs were shown to elevate the level of nerve growth factor mRNA and at the same time, produce no effect on its level in intact animals. The neuroactivating action of CNTF in the acute phase of hemorrhagic stroke was achieved by intranasal administration due to the retrograde axon transport of CNTF molecules along the olfactory nerve fibers to the brain, by passing the blood-brain barrier. It was ascertained that the molecules of tritium-labeled CHTF accumulated in the central nervous system following 20 minutes and the level of label accumulation is proportionally increased after 120 minutes. The pattern of accumulation of the intranasally administered label in the olfactory tract and olfactory bulb proves CNTF transportation along these structures of the nervous system. Therefore, when intranasally administered, CNTFs are able to transport to the central nervous system along the olfactory tract and to enhance the expression of nerve growth factor mRNA in hemorrhagic stroke.