The role of lymphocyte-platelet adhesions, cytokines and endothelial dysfunction in pathogenesis of cold-induced lesions
Shapovalov, K.G.; Tomina, E.A.; Mikhaĭlichenko, M.I.; Vitkovskiĭ, I.A.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1: 39-40 Following 40
2009
ISSN/ISBN: 0031-2991 PMID: 19382624 Document Number: 635702
We studied the role of lymphocyte-platelet adhesion, IL-1beta, TNFalpha and endothelial dysfunction in pathogenesis of damage in local frostbites. Examination of 60 patients aged 17-50 years with frostbites of the second-forth degree has demonstrated that in patients with local frostbites the number of lymphocyte-platelet adhesions, circulating desquamated endothelial cells increases as well as the level of proinflammatory cytokines, while nitrites concentration decreases.