Fatal outcome of spontaneous cerebral and intraventricular hemorrhage in a child with idiopathic thrombocytopenic purpura (ITP) --case report
Brodkiewicz, A.; Peregud-Pogorzelski, Jław.; Szychot, E.; Badowicz, B.; Pakulski, C.; Marciniak, H.
Annales Academiae Medicae Stetinensis 55(1): 11-3; Discusison 14
2009
ISSN/ISBN: 1427-440X PMID: 20349586 Document Number: 635498
Idiopathic thrombocytopenic purpura (ITP) is the most prevalent acquired hemorrhagic diathesis in children characterised by antibody-mediated destruction of platelets. ITP is generally a self-limiting benign disorder but despite this good prognosis, ITP carries the risk of severe bleeding (mainly intracranial) that may threaten the child's life. We describe a case of a 5-year-old girl with idiopathic thrombocytopenic purpura in the course of EBV infection with massive cerebral and intraventricular hemorrhage and fatal outcome. This extremely rare case of intracranial haemorrhage in a child with ITP coexisting with EBV infection (a likely additional risk factor for hemorrhage) deserves attention considering the fatal outcome despite intensive treatment.