Determinants of long-term survival after pancreaticoduodenectomy for ampulla of Vater carcinoma
Chen, J.-y.; Cai, S.-w.; Zhang, W.-z.; Huang, X.-q.; Liu, R.; Wang, J.; Chen, Y.-l.; Ji, W.-b.; Shi, X.-j.; Chen, M.-y.; Liu, Z.-w.; Zhao, X.-q.; Feng, Y.-q.; Huang, Z.-q.; Dong, J.-h.
Zhonghua Yi Xue Za Zhi 89(48): 3409-3412
2009
ISSN/ISBN: 0376-2491 PMID: 20223115 Document Number: 634724
To investigate the determinants of long-term survival for ampulla of Vater carcinoma treated by pancreaticoduodenectomy. A total of 77 patients with ampulla of Vater carcinoma undergoing pancreaticoduodenectomy were reviewed. Kaplan-Meier method was used to analyze the survival rate. Independent t test was used for statistical comparison and COX regression model for multivariate analysis. No patient died as a result of surgery. The overall 5-year survival was 40.7%. Univariate analysis showed that perioperative serum carcinoembryonic antigen (CEA) level (P = 0.012), tumor invasion depth (P = 0.000), UICC stage (P = 0.000) and tumor size (P = 0.001) were significant prognostic factors of ampulla of Vater carcinoma; in multivariate analysis, only the tumor size (P = 0.000) was an independent prognostic factor of ampulla of Vater carcinoma. Pancreaticoduodenectomy is associated with significant survival. Tumor size is the most important influencing factor of outcome after pancreaticoduodenectomy; in addition, perioperative serum CEA level, tumor invasion depth and UICC stage may also influence the survival rate, there exists a need for further follow-up studies.