The complex relationship between magnesium and serum parathyroid hormone: a study in patients with chronic intestinal failure
Pironi, L.; Malucelli, E.; Guidetti, M.; Lanzoni, E.; Farruggia, G.; Pinna, A.D.; Barbiroli, B.; Iotti, S.
Magnesium Research 22(1): 37-43
2009
ISSN/ISBN: 0953-1424 PMID: 19441273 Document Number: 634215
In this study we compared the content of muscle free [Mg2+] assessed by 31P MRS to that of serum total Mg assessed by routine colorimetric assays in 15 patients affected by Chronic Intestinal Failure (CIF) on long-term Home Parenteral Nutrition (HPN) or who had undergone isolated intestinal transplantation. We also investigated in the same cohort of patients the relationship of muscle free [Mg2+] and serum total Mg with parathyroid hormone (PTH) serum content. All patients showed a normal cytosolic free [Mg2+] in the calf muscle despite about half of them having a content of total serum [Mg] below or at the lower edge of the boundary limits. Muscle free Mg2+ and serum total Mg displayed an opposite correlation versus serum PTH, showing that the intracellular free form possesses a different functional metabolic meaning in the regulation of PTH secretion.