Steroidogenesis-related proteins expression in skin cells
Ruksha, T.G.
Tsitologiia 51(11): 940-944
2009
ISSN/ISBN: 0041-3771 PMID: 20058813 Document Number: 634175
Peripheral benzodiazepine receptor (PBR, TsPO) is an outer mitochondrial membrane protein which is implicated in steroid biosynthesis regulation, apoptosis and cell proliferation. Immunocytochemical assay revealed decreased levels of PBR, its endogenous ligand DBI and cytochrome P450scc in malignant skin cells in comparison to normal keratinocytes and melanocytes. These data indicate diminished steroidogenesis in skin cancer.
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