Study on the association between chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 allele
Liang, H-Xia.; Yu, Z-Jiang.; Jiang, H-Qing.
Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 23(4): 302-303
2009
ISSN/ISBN: 1003-9279 PMID: 20108780 Document Number: 633483
To investigate the association between the chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 gene. HLA-DRB1 * 1301,1302 allele in 27 patients with chronic hepatitis B cirrhosis and 30 patients with chronic hepatitis B was analyzed by using the polymerase chain reaction/sequence specific primer (PCR-SSP) technique. The frenquency of HLA-DRB1 * 1301,1302 allele in the chronic hepatitis B cirrhosis group was markly higher than that in the chronic hepatitis B group. HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to chronic hepatitis cirrhosis.