Pulmonary lymphangioleiomyomatosis: report of one case
Silva O, R.; Puelma C, F.; Retamal P, Víctor.; Rojas Sm, P.; Cruzat C, C.; Reyes G, C.
Revista Medica de Chile 137(11): 1474-1477
2009
ISSN/ISBN: 0034-9887 PMID: 20098807 Document Number: 632798
Lymphangioleiomyomatosis (LAM) is a rare interstitial lung disease, of unknown etiology, affecting almost exclusively women. Microscopically LAM consists of a diffuse proliferation of smooth muscle cells. LAM can occur without evidence of other diseases (sporadic LAM) or in conjunction with tuberous sclerosis complex (TSC). It presents with progressive breathlessness or with recurrent pneumothorax or chylothorax. We report a 33 year-old woman with a history of recurrent pneumothorax. Computed tomography (CT) scans showed numerous thin-walled cysts throughout the lungs, a characteristic finding in LAM. A pulmonary biopsy was compatible with the diagnosis and HMB-45 monoclonal antibodies were positive. Treatment with Sirolimus was started).