Progress in the study of micelle delivery system reversing multidrug resistance
Diao, Y-Yuan.; Han, M.; Chen, D-Wei.; Gao, J-Qing.
Yao Xue Xue Bao 44(7): 710-715
2009
ISSN/ISBN: 0513-4870 PMID: 19806907 Document Number: 632249
Multidrug resistance (MDR) of cancer cells to anti-tumor drugs remains a major impediment to successful chemotherapy. There has been an increasing interest in the studies of the mechanism and reverse of the MDR. Being a reliable and safe way to reverse MDR, drug delivery systems (DDS) such as micelle, liposome and nanoparticle, represent a promising prospect both in research and application in recent years. On the basis of recent studies, the effect and mechanism of micelles on reversing MDR are reviewed. And it is anticipated that DDS could contribute greatly to reversing MDR in the future.