Recognition and modulation of Dectin-1 and TLR-2 receptors by curdlan derivatives and purified natural extracts
Călugăru, A.; Cremer, L.; Lupu, A.R.; Bădulescu, M.M.; Apetrei, N.S.; Moscovici, M.; Mocanu, G.; Mihai, D.; Kerek, F.; Szegli, G.
Roumanian Archives of Microbiology and Immunology 68(3): 119-124
2009
ISSN/ISBN: 1222-3891 PMID: 20361531 Document Number: 632065
Toll-like receptors (TLRs) and Dectin-1, as members of Pattern Recognition Receptors play an essential role in innate immune response against bacteria and fungi respectively, contributing to pathogens recognition, phagocytosis, etc. Dectin-1 and TLR-2/TLR-6 can interact for intracellular signal transduction. Dectin-1 is expressed at low levels on macrophages and at high levels on dendritic cells. Dectin-1 and TLRs are synergistic in mediating cytokines production, such as IL-12 and tumor necrosis factor alpha (TNF alpha). In the present paper we studied the expression of Dectin-1 (beta-Glucan Receptor C-type lectin receptor class V) and TLR-2 on human normal monocytes cells and also the role of different Curdlan derivatives and highly purified natural extracts, especially their capacity to recognize these receptors and their Dectin-1 agonist/antagonist properties. Our results demonstrated that Curdlan derivatives containing sulfopropyl or palmythoil/carboximethyl/sulfopropyl groups and natural extracts could be potent immunomodulators with many potential applications (possible antagonists of Dectin-1, blockers of Dectin-1 cooperation with TLR-2).
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