Efficacy of cellulose on functional constipation
Liu, B.-h.; Yang, X.-q.; Ren, D.-l.; Ding, Y.-j.; Zhao, K.; Qian, Q.; Yang, G.-g.; Wang, D.
Zhonghua Wei Chang Wai Ke Za Zhi 12(2): 182-184
2009
ISSN/ISBN: 1671-0274 PMID: 19296258 Document Number: 631337
To assess the clinical efficacy and safety of cellulose on functional constipation. A prospective, self-controlled, multicenter clinical trial of cellulose was conducted for 2 weeks in 240 patients with functional constipation according to the Rome III( criteria. Symptoms and characters of feces before and after the treatment were observed and evaluated according to a score scheme. In the 240 patients, the frequencies of defecation increased and the characters of feces was improved significantly after 2-week treatment. There were no adverse reactions observed throughout the clinical trial. The total efficacy was 82.1% at day 7 and 90.7% at day 14. The satisfactory rate of doctors was 83.8% and of patients was 83.8%. Cellulose is effective and safe in the treatment of chronic functional constipation.