Neuroimmunological mechanisms of development of occupational nervous system lesions
Bodienkova, G.M.; Rukavishnikov, V.S.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 3: 6-9
2009
ISSN/ISBN: 0031-2991 PMID: 19916321 Document Number: 631248
One hundred and fifty fire liquidators, including 68 persons with consequences of acute intoxication with a complex of toxic substances, were examined over time. The development of occupational nervous system injuries was shown to be followed by systemic immunological disorders. Following 8 years, the patients with occupational neurointoxication were found to have impaired processes of lymphocytic activation (higher lymphocytes expressing CD25 and CD95) in the presence of significant immunosuppression. There was evidence for the involvement of autoimmune reactions in the formation of an immune response to a complex of toxic substances, as suggested by the high level of autoantibodies to nervous tissue antigens and dDNA. In addition to impaired immunoregulation, the established association between HLA antigens and the development of a disease also plays an important role in the development of toxic encephalopathy.