Second-line therapy for patients with Helicobacter pylori eradication failure
Satoh, K.
Nihon Rinsho. Japanese Journal of Clinical Medicine 67(12): 2297-2302
2009
ISSN/ISBN: 0047-1852 PMID: 19999115 Document Number: 630734
Meta-analyses showed that quadruple therapy, ranitidine bismuth-based triple therapy and levofloxacin-based triple therapy were the most effective for the second-line H. pylori eradication therapy. In Japan, many studies showed that triple therapy with proton pump inhibitor (PPI), amoxicillin (AMPC) and metronidazole was effective after eradication failure using triple therapy with PPI, AMPC and clarithromycin. The intention-to-treat eradication rates were 81-97%, and the incidence rates of adverse events were 8-33%.