Peripheral blood circulation in the skin and the regulatory mechanisms in the course of primary transmural myocardial infarction
Khalepo, O.V.; Molotkov, O.V.; Eshkina, S.L.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 4: 11-15
2009
ISSN/ISBN: 0031-2991 PMID: 20146405 Document Number: 630628
Laser Doppler flowmetry was used to study the indicators characterizing the peripheral blood circulation in the skin, regulatory mechanisms, and the compensatory capacities of the microcirculatory bed in 32 patients aged 45-60 years in the course of primary transmural myocardial infarction during exercise tests. Significant disturbances of the mechanism responsible for regulating the peripheral blood circulation system and chiefly its active components were detected in the presence of adequate blood filling of microvessels. There was a drastic decrease in the reserves of skin microvascular endothelial activity during ionophoresis of sodium nitroprusside and acetylcholine, the maximum degree of disturbances being observed on day 10 of myocardial infarction development.