Poorly differentiated prostate cancer may be associated with cytomegalovirus infection in prostatic tissue
Andabekov, T.T.; Klochkova, T.G.; Urbanskiĭ, A.I.; Samsonov, R.B.; Shkol'nik, M.I.; Evtushenko, V.I.; Karelin, M.I.
Voprosy Onkologii 55(2): 183-186
2009
ISSN/ISBN: 0507-3758 PMID: 19514372 Document Number: 630580
Polymerase chain-reaction procedure was used to test archival samples of prostate tissue from 90 cancer patients for cytomegalovirus infection detected in 46.7%. The median Gleason score and G-index (TNM classification) were significantly higher in CMV-positive patients (8 and 4, respectively) than those in CMV-negative ones (6 and 2, respectively). A relationship between cytomegalovirus infection and poor prognosis of prostate cancer is suggested.