Disseminated intravascular coagulation in experimentally induced feline infectious peritonitis

Weiss, R.C.; Dodds, W.J.; Scott, F.W.

American Journal of Veterinary Research 41(5): 663-671

1980


ISSN/ISBN: 0002-9645
PMID: 6250426
Document Number: 63
Disseminated intravascular coagulation was induced in kittens by intraperitoneal inoculation of feline infectious peritonitis virus (FIPv). Kittens seronegative to FIPV survived significantly (P<0.05) longer than those seropositive to FIPV. Pyrexia, anemia, icterus, hyperbilirubinemia, and elevated concentrations of liver-specific enzymes were detected in the inoculated cats. Lesions induced included disseminated fibrinonecrotic and pyogranulomatous inflammation, hepatic necrosis, and widespread phlebitis and thrombosis. Localization of FIP viral antigen and immunoglobulin G was demonstrated in foci of hepatic necrosis by immunofluorescence microscopy. Lymphopenia, thrombocytopenia, hyperfibrinogenemia, and increased quantities of fibrin-fibrinogen degradation products were present in cats after the onset of clinical illness. Depression of factor VII, VIII, IX, X, XI, and XII plasma activities and prolongation of prothrombin and partial thromboplastin times also developed in infected cats. The accelerated onset of clinical disease and mortality in seropositive kittens vs seronegative kittens and the association of virus and antibody in multiple foci of hepatic necrosis suggest an immune-mediated component is involved in the pathogenesis of this disease.

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Disseminated intravascular coagulation in experimentally induced feline infectious peritonitis