Multicenter phase Ii trial of first-line docetaxel/gemcitabine in advanced breast cancer pretreated with adjuvant anthracyclines
Vici, P.; Giotta, F.; DI Lauro, L.; Brandi, M.; Gebbia, V.; Foggi, P.; Lorusso, V.; Vitucci, C.; Sergi, D.; Fattoruso, S.I.; Giannarelli, D.; Viola, G.; Corsetti, S.; Colucci, G.; Lopez, M.
Anticancer Research 29(5): 1841-1845
2009
ISSN/ISBN: 0250-7005 PMID: 19443414 Document Number: 629984
The aim of this study was to evaluate activity and tolerability of docetaxel-gemcitabine combination as first-line treatment in patients with metastatic breast cancer previously treated with adjuvant anthracyclines. Sixty-eight women received gemcitabine 1,000 mg/m(2) as 30-minute infusion on days 1 and 8, and docetaxel 80 mg/m(2) as 1-hour infusion on day 8, with cycles repeated every 3 weeks. Objective responses were observed in 32 out of 68 evaluable patients (45%; 95% confidence interval, 35.2-58.8%). Responses were 44%, 42%, 49% in soft tissue, bone and visceral lesions, respectively, 50% /52% in HER2-positive/-negative tumors, and 50% in both ER- positive/-negative tumors. Median time to progression and overall survival were 6 and 16 months, respectively. Treatment was usually well tolerated, with grade 3-4 neutropenia in 32% - 7% of the patients, and neutropenic fever, grade 3 vomiting, mucositis and peripheral neurotoxicity in 3% of the patients. Gemcitabine-docetaxel combination is effective and well tolerated as first-line treatment in advanced breast cancer previously treated with adjuvant anthracyclines.