Optimisation of treatment of Parkinson's disease with levodopa
Białecka, M.; Adamiak, U.; Gawrońska-Szklarz, B.
Neurologia i Neurochirurgia Polska 43(5): 446-459
2009
ISSN/ISBN: 0028-3843 PMID: 20054747 Document Number: 629182
This article presents the major strategies for individualisation and optimisation of levodopa therapy. The relationship between pharmacokinetic and pharmacodynamic effects of levodopa is discussed. Pharmacokinetic parameters in different stages of Parkinson's disease are interpreted. Moreover, the main differences in pharmacokinetics of levodopa formulations and routes of administration are presented. The authors also suggest methods to increase efficacy and safety of levodopa therapy in patients with Parkinson's disease.