Stromal cells play a role in cervical cancer progression mediated by MMP-2 protein
Fernandes, T.; de Angelo-Andrade, L.A.; Morais, S.S.; Pinto, G.A.; Chagas, C.A.; Maria-Engler, S.S.; Zeferino, L.C.
European Journal of Gynaecological Oncology 29(4): 341-344
2008
ISSN/ISBN: 0392-2936 PMID: 18714566 Document Number: 628261
Metalloproteinases, especially metalloproteinase-2 (MMP-2), are known for their role in the degradation of the extracellular matrix. Nevertheless, a thorough understanding of MMP-2 expression in neoplastic lesions of the uterine cervix has yet to be accomplished. This study aimed to analyze the MMP-2 expression in cervical intraepithelial neoplasia III (CIN3) and in cervical squamous cell carcinoma, in tumor cells and adjacent stromal cells. MMP-2 expression was assessed by an immunohistochemical technique. MMP-2 expression was greater in the stromal cells of invasive carcinomas than in CIN3 (p < 0.0001). MMP-2 expression in stromal cells correlates with the clinical stage, gradually increasing as the tumor progresses (p = 0.04). This study corroborates that stromal cells play an important role in tumor invasion and progression, mediated by the progressive enhancement of MMP-2 expression from CIN3 to advanced invasive tumor. The intense MMP-2 expression most probably is associated with poor tumor prognosis.