Embryonal rhabdomyosarcoma of the chest wall: a case report and review of the literature
Mysorekar, V.V.; Harish, K.; Kilara, N.; Subramanian, M.; Giridhar, A.G.
Indian Journal of Pathology and Microbiology 51(2): 274-276
2008
ISSN/ISBN: 0377-4929 PMID: 18603708 Document Number: 627559
Embryonal rhabdomyosarcoma is a soft-tissue sarcoma which has a predilection for the head and neck area, genitourinary tract and the extremities. We report a rare case of embryonal rhabdomyosarcoma of the chest wall in an 8-year-old girl, presenting as a destructive tumor in the rib and clinically and radiologically mimicking Ewing's sarcoma. Histopathological examination showed a small round cell tumor. Immunohistochemically, the positivity for muscle markers desmin and myogenin in the tumor cells proved to be useful for making a definitive diagnosis of embryonal rhabdomyosarcoma. Cytogenetic analysis revealed a high level of aneuploidy in the tumor cells, with double-minutes and additional chromosomal structural aberrations. The patient is responding well to chemotherapy.