CCR5 Expression Levels in HIV-Uninfected Women Receiving Hormonal Contraception
Sciaranghella, G.; Wang, C.; Hu, H.; Anastos, K.; Merhi, Z.; Nowicki, M.; Stanczyk, F.Z.; Greenblatt, R.M.; Cohen, M.; Golub, E.T.; Watts, D.H.; Alter, G.; Young, M.A.; Tsibris, A.M.N.
Journal of Infectious Diseases 212(9): 1397-1401
2015
ISSN/ISBN: 1537-6613 PMID: 25895986 DOI: 10.1093/infdis/jiv233Document Number: 627259
Human immunodeficiency virus (HIV) infectivity increases as receptor/coreceptor expression levels increase. We determined peripheral CD4, CCR5, and CXCR4 expression levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the levonorgestrel-releasing intrauterine device (LNG-IUD; n = 27), oral contraceptive pills (n = 32), or no hormonal contraception (n = 33). The use of LNG-IUD increased the proportion of CD4(+) and CD8(+) T cells that expressed CCR5; increases in the magnitude of T-cell subset CCR5 expression were observed with DMPA and LNG-IUD use (P < .01 for all comparisons). LNG-IUD and, to a lesser extent, DMPA use were associated with increased peripheral T-cell CCR5 expression.