Effect of pregnancy and the postpartum period on adherence to antiretroviral therapy among HIV-infected women established on treatment

Henegar, C.E.; Westreich, D.J.; Maskew, M.; Miller, W.C.; Brookhart, M.A.; Van Rie, A.; Henegar, C.E; Westreich, D.J; Maskew, M; Miller, W.C; Brookhart, M.A; Van Rie, A

doi:10.1097/qai.0000000000000501

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Effect of pregnancy and the postpartum period on adherence to antiretroviral therapy among HIV-infected women established on treatment

Henegar, C.E.; Westreich, D.J.; Maskew, M.; Miller, W.C.; Brookhart, M.A.; Van Rie, A.

Journal of Acquired Immune Deficiency Syndromes 68(4): 477-480

2015

ISSN/ISBN: 1944-7884

PMID: 25559590

DOI: 10.1097/qai.0000000000000501

Document Number: 627219

: Among women who become pregnant after initiating highly active antiretroviral therapy (HAART), few data describe the effect of pregnancy and postpartum on adherence. We conducted a retrospective clinical cohort study among therapy-naive women (age, 18-45 years) initiating HAART in Johannesburg, South Africa. Among 7510 women in our analysis, 896 experienced a pregnancy after starting HAART. Compared with nonpregnant periods of follow-up, there was an increased risk of nonadherence during the postpartum period (weighted risk ratio: 1.46, 95% confidence interval: 1.17 to 1.82) but not during pregnancy itself (weighted risk ratio: 0.95, 95% confidence interval: 0.78 to 1.17).