The signaling mechanism of glucocorticoid-induced T-cell apoptosis
Okabe, T.; Takayanagi, R.; Yanase, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 66(1): 94-97
2008
ISSN/ISBN: 0047-1852 PMID: 18193548 Document Number: 627039
Glucocorticoid-induced T-cell apoptosis is supposed to require the change of gene expression. Enhanced expression of proapoptotic gene or inhibited expression of antiapoptotic gene seems to be necessary, although the real target gene remain to be elucidated. Recently, it was reported that extracellular signal-regulated protein kinase (ERK) inhibits glucocorticoid-induced T-cell apoptosis. This finding might provide new tools for overcoming glucocorticoid-resistance.