Membrane proteins as diagnostic biomarkers and targets for new therapies
Josic, D.; Clifton, J.G.; Kovac, S.; Hixson, D.C.
Current Opinion in Molecular Therapeutics 10(2): 116-123
2008
ISSN/ISBN: 1464-8431 PMID: 18386223 Document Number: 626035
Membrane proteins, especially plasma membrane proteins, form one of the most interesting classes of proteins among disease biomarker candidates. Because of their localization on the surface of cells and organelles, membrane proteins also represent potential drug targets. In this review, developments in the characterization of membrane proteins and their role in the treatment of disease, in particular cancer treatment, are presented.