Oral contraceptive use and saliva diurnal pattern of metabolic steroid hormones in young healthy women
Vibarel-Rebot, N.; Rieth, N.; Lasne, F.; Jaffré, C.; Collomp, K.
Contraception 91(3): 245-247
2015
ISSN/ISBN: 1879-0518 PMID: 25592051 DOI: 10.1016/j.contraception.2014.11.010Document Number: 624968
The impact of oral contraceptives (OCs) on the saliva diurnal pattern of metabolic steroid hormones remained unknown. Saliva samples were taken from young healthy women (11 OC users, 10 non-OC users) to analyze cortisol, dehydroepiandrosterone (DHEA) and testosterone 4 times (days 1, 8, 15 and 22) over one menstrual cycle. OC use decreased saliva testosterone concentrations (p<.01) under all conditions of day and time, but not saliva cortisol. OC also decreased saliva DHEA concentrations during the first part of the day (p<.05), with a dampened amplitude in its diurnal pattern. The clinical relevance requires further study.
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