Pathological changes of potential-activated calcium channels in sensory neurons
Kostiuk, O.P.; Pinchenko, V.O.; Kostiuk, P.H.
Fiziolohichnyi Zhurnal 54(3): 81-91
2008
ISSN/ISBN: 2522-9028 PMID: 18763584 Document Number: 623440
The review considers the structure and function of high-and low-voltage potential activated calcium channels in sensory neurons. A special attention is paid to compression of the function of these channels in normal conditions and during development of pathological conditions. The role of low-voltage activated T-type calcium channels during such forms of pathology as neuropathy, acidosis and alkalosis because the changes in synaptic transmission occurring during these forms of pathological changes are most intensively altered during changes in functional structures of these type of channels. During studying of high-voltage activated calcium channels main attention has been concentrated on changes in the function of N-type potential activated calcium channels.