Serum triglyceride is an independent risk factor for acute coronary heart disease events in 35 - 64 years old Chinese-Chinese Multi-provincial Cohort Study.
Wang, M.; Zhao, D.; Wang, W.; Liu, J.; Liu, J.; Liu, S.; Sun, J-Yi.; Qin, L-Ping.; Wu, Z-Su.
Zhonghua Xin Xue Guan Bing Za Zhi 36(10): 940-943
2008
ISSN/ISBN: 0253-3758 PMID: 19102897 Document Number: 622451
To evaluate the association between serum triglyceride (TG) and the cardiovascular diseases (CVD) risk in Chinese population. A total of 30, 378 men and women aged 35 - 64 years old were recruited in the Chinese-Chinese Multi-provincial Cohort Study (CMCS). The serum TG and other CVD risk factors were measured. All subjects were followed up annually or biannually for acute CVD events from 1992 to 2004. A Cox regression model was established to identify the association between TG and risk of CVD events. The accumulative incidence rate of acute coronary heart disease (CHD) events increased from 62.6/100 000 in the low TG groups to 168.4/100 000 in the high TG group divided by the quartile. TG was identified as an independent risk factor for CHD after adjustment for the confounding risk factors by a Cox regression model. Compared subjects with TG < 0.81 mmol/L, CHD risk increased 81% and 59% in subjects with TG 1.15 - 1.59 mmol/L and TG >/= 1.60 mmol/L, respectively (all P < 0.05). There was no significant association between TG level and the risks of hemorrhagic and ischemic stroke events (P > 0.05). Serum TG is an independent risk factor for acute CHD events in Chinese population aged 35 - 64.