Gene regulation by steroid receptors
Takada, I.; Kato, S.
Nihon Rinsho. Japanese Journal of Clinical Medicine 66(1): 65-69
2008
ISSN/ISBN: 0047-1852 PMID: 18193545 Document Number: 621591
Steroid hormone receptors are ligand-dependent transcriptional factors and regulate cell differentiation, proliferation, and homeostasis. Recently, many target genes of steroid hormone receptors were identified by genome-wide analysis and associated cofactors were also identified by proteomics analysis. From these findings, the molecular mechanism of ligand-dependent transactivation function of steroid hormone receptors have been elucidated. However, tissue specific regulation and extracellular signal-dependent regulation of steroid hormone receptor function are still under investigation.