Fentanyl pre-treatment alleviates pain during injection of propofol-lipuro premixed with lignocaine
Ahmad, N.; Zanariah, Y.; Balan, S.
Medical Journal of Malaysia 63(5): 431-433
2008
ISSN/ISBN: 0300-5283 PMID: 19803312 Document Number: 621494
We studied the effect of fentanyl pretreatment on alleviating pain during the injection of Propofol-Lipuro. One hundred and seventy patients were randomly allocated to receive either 100 mcg of intravenous fentanyl or normal saline (placebo) followed by intravenous Propofol-Lipuro premixed with 20 mg lignocaine. The incidence of injection pain was 32% and 13% in the placebo and fentanyl groups, respectively. We found a statistically significant reduction in incidence of injection pain in the fentanyl group when compared with the placebo group (p<0.003). The number needed to treat was 6 (3.2< 95% CI <15.1). In conclusion, fentanyl pretreatment is effective in alleviating pain during injection of Propofol-Lipuro.