Brooke-Spiegler syndrome: report of a case of multiple cylindromas and trichoepitheliomas
Doherty, S.D.; Barrett, T.L.; Joseph, A.K.
Dermatology Online Journal 14(7): 8
2008
ISSN/ISBN: 1087-2108 PMID: 18718192 Document Number: 621261
We report a case of Brooke-Spiegler syndrome, a rare autosomal dominant disorder caused by mutations of the cylindromatosis gene (CYLD) tumor suppressor gene resulting in multiple cylindromas and trichoepitheliomas. Treatment of these patients can involve surgical excision, laser therapy, or topical applications of aspirin derivatives.
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