Studies on pharmacokinetics of artemether patch in mice
Yang, H.-s.; Ye, Z.-g.; Liang, B.-w.; Wang, N.-j.; He, C.; Li, J.-s.
Zhongguo Zhong Yao Za Zhi 33(12): 1459-1462
2008
ISSN/ISBN: 1001-5302 PMID: 18837356 Document Number: 620999
To establish a HPLC-MS-MS determination method of artemether (ARM) and active derivatives DHA, and compare the pharmacokinetic parameters of ARM after transdermal and oral administration. The mice were divided two groups (transdermal and oral) by parallel design. ARM and active derivatives DHA in plasma of mice at different sampling time were determined. The pharmacokinetic parameters were calculated by DAS 2.0 and by statistic analysis. compare oral administration, the pharmacokinetic parameters of ARM after transdermal, Cmax Tmax , AUC(0-t) MRT, had significant difference (P < 0.05). The artemether patch has long-releasing property.