Efficacy and safety of enoxaparin use during drug-eluting stents implantation
Mustafaoglu, F.; Petrakova, L.N.; Pershukov, I.V.; Batyraliev, T.A.; Pia, I.V.; Lazarev, I.A.; Ramazanov, D.M.; Shul'zhenko, L.V.; Kadyrov, B.K.; Sal'nikov, D.V.; Dolgikh, N.N.; Sidorenko, B.A.
Kardiologiia 48(6): 28-34
2008
ISSN/ISBN: 0022-9040 PMID: 18729833 Document Number: 620992
We assessed possibility of the use of low molecular heparin enoxaparin during percutaneous coronary interventions (PCI) with implantation of drug eluting stents. Enoxaparin was administered to 225 (0.3 mg/kg intraarterially via catheter) and 215 (0.5 mg/kg intravenously) patients. In comparison group (n=207) we used unfractionated heparin (UFG) intravenously according to standard scheme under control of activated clotting time. Stents implanted (n=797) were Cypher, Taxus, and Endeavor. Immediate angiographic success was 100%. During 48 hours after PCI pronounced bleeding (4.3%) and blood transfusions predominated in UFG treated patients. Number of bleedings was minimal after the intra-arterial use of enoxaparin (0.3 mg/kg). However total rate of all adverse events after PCI turned out to be minimal (7.0%) in the group of patients receiving enoxaparin intravenously (0.5 mg/kg). Thus the use of low molecular heparin enoxaparin is justified during implantation of drug eluting stents. Its optimal dose according to data obtained is 0.5 mg/kg intravenously.