Cell therapy for myocardial infarction
Krugliakov, P.V.; Sokolova, I.B.; Polyntsev, D.G.
Tsitologiia 50(6): 521-527
2008
ISSN/ISBN: 0041-3771 PMID: 18727403 Document Number: 620711
The review discusses cell therapy; one of the most promising approaches to myocardial infarction treatment. The possibility to use cell material of various origins is analyzed. The review sums up data on the application of fetal and neonatal cardiomyocytes, myoblasts, bone marrow mononuclear fraction, hematopoietic and mesenchymal stem cells (MSX) as cell therapy agents. The conclusion is made that MSC are promising cell material for myocardial infarction therapy. MSC are able to migrate to the injured area, differentiate into myocardial lineage. They produce a wide range of factors that stimulate angiogenesis and increase viability of cells, including cardiomyocytes.