Dys-synchronous regulation of XPC and XPA in trigeminal ganglion neurons following cisplatin treatment cycles
Guthrie, O.W.
Anticancer Research 28(5a): 2637-2640
2008
ISSN/ISBN: 0250-7005 PMID: 19035288 Document Number: 620417
Cancer cells may survive cisdiamminedichloroplatinum-II (cisplatin) DNA damage through synchronous mobilization of DNA repair proteins such as xeroderma pigmentosum C and A (XPC and XPA). However, non-cancerous neuronal cells exhibit hyper-vulnerability to cisplatin which is manifest as peripheral neurotoxicity. The purpose of the present study was to evaluate the effect of cisplatin on the immunolocalization of XPC and XPA in the trigeminal ganglion. Fischer344 rats were treated with two cycles of cisplatin (2 mg/kg/day, i.p.) and tissues were harvested for immunohistochemistry after each treatment cycle. XPA immunoreactivity was evident after each treatment cycle, however, XPC immunoreactivity was suppressed following the second treatment cycle. The hyper-vulnerability of peripheral neurons to cisplatin chemotherapy may relate to the dys-synchronous regulation of XPC and XPA.