Expression of TGF-beta receptors in CD8+ T cells of oral lichen planus
Lei, L.; Yu, M.; Gao, X.-Y.; Zhou, X.-L.; Zhan, L.-H.
Zhonghua Kou Qiang Yi Xue Za Zhi 43(2): 99-100
2008
ISSN/ISBN: 1002-0098 PMID: 18683732 Document Number: 620112
To investigate the expression of TGF-beta receptors in CD8+ T cells of oral lichen planus (OLP). Immunohistochemical double labeling technique was used to examine the expression of TGF-betaR I and TGF-betaR II in CD8+ T cells of 28 OLP patients and in 10 controls. The results were compared between the two groups. The double labeled cells were negative in controls. The positive rates of double labeled cells of CD8+/TGF-betaR I and CD8+/TGF-betaR II in OLP were (8.82 +/- 9.98)% and (1.11 +/- 2.94)% respectively. The expression level of TGF-betaR II in CD8+ T cells of OLP did not increase compared with the controls, but the expression of TGF-betaR I increased. The results indicate the abnormal TGF-beta signal transduction in CD8+ T cells of OLP, which may contribute to the persistence of the chronic inflammation in OLP.