Pharmacological significance of alpha lipoic acid in up to date treatment of diabetic neuropathy
Becić, F.; Kapić, E.; Rakanović-Todić, M.
Medicinski Arhiv 62(1): 45-48
2008
ISSN/ISBN: 0025-8083 PMID: 18543755 Document Number: 619980
Alpha lipoic acid is important intramolecular redox system. It is coenzyme of piruvate dehydrogenase and ketoglutarate dehydrogenase. Alpha lipoic acid has enzymatic and cytoprotective effect. It has key role in citric acid cycle, as a coenzyme. Therapeutic efficacy of alpha lipoic acid in diabetic neuropathy is based on reaction with free radicals and lipophylic antioxydans properties. Clinical studies results showed efficacy and safety of alpha liponic acid application in patients with diabetic neuropathy.