The bone tissue remodeling in young and adult rats in conditions of alimentary deprivation
Litovka, I.H.; Kostiuchenko, O.S.
Fiziolohichnyi Zhurnal 54(2): 69-74
2008
ISSN/ISBN: 2522-9028 PMID: 18589689 Document Number: 619664
We studied the influencing of designed during 28 days alimentary deprivation on the bone tissue physiological remodeling processes for 3- and 9-monthly Wistar rats-males (n=32). 4 groups of animals are probed: I, III - control, II, IV is the mode of calorie limitation (40% in relation to a valuable ration for every age group). It is shown, that alimentary deprivation increase the concentration of melatonin, glycosaminoglycans in blood serum and activity ofalkaline phosphatase in serum and bone tissue in 1,4 and 1,2 time accordingly at for young rats. For adult rats the reliable decline of activity of alkaline phosphatase is exposed in the blood serum after alimentary deprivation. Expression of gene ofinsulinlike growth factor-I for animals of both probed groups did not change practically. We conclude, that alimentary deprivation change the biochemical markers of bone tissue physiological remodeling for young animals, while the changes of physiological regeneration rates were insignificant for adult animals.