Stability of physical state on compound hawthorn dropping pills
Zhang, W.; Chen, H.-Y.; Jiang, J.-L.
Zhongguo Zhong Yao Za Zhi 33(21): 2474-2478
2008
ISSN/ISBN: 1001-5302 PMID: 19149251 Document Number: 619531
To evaluate the stability of physical state with accelerate test and dropping in process before and after on compound hawthorn dropping pills. Scanning electron microscope, TG-DTA, FT-IR and XRD were used. The active components presented amorphous, tiny crystal and molecular state in dropping pills, and it had no obvious reaction between PEG 4000 and active components. With time prolonging, a little of active components changed from amorphous state to tiny crystal or molecular state. Solid dispersion improved the stability and dissolution of compound hawthorn dropping pills.