Inflammatory bowel disease--the role and issue of glucocorticoid
Ashida, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 66(1): 137-141
2008
ISSN/ISBN: 0047-1852 PMID: 18186257 Document Number: 618451
We herein reviewed the clinical applications of glucocorticoid (GC) hormones to inflammatory bowel disease (IBD). In the therapeutic strategy for active ulcerative colitis, topical/systemic GC administration is still central during these fifty years. However, non -responders to GC are present at 30-40% of the active UC patients. We analyzed the expression of GC receptor isoform, namely hGRbeta, in peripheral blood mononuclear cells, and suggest the possibility that expression of hGRbeta, induced by proinflammatory cytokine IL-18, is closely related GC resistance in UC.