Biological treatment options for Graves' ophthalmopathy
El Fassi, D.; Nielsen, C.H.; Hegedüs, L.
Ugeskrift for Laeger 170(24): 2128-2130
2008
ISSN/ISBN: 1603-6824 PMID: 18565294 Document Number: 618011
The current medical treatment options for Graves' ophthalmopathy (GO) are unsatisfactory. Recent treatment of GO patients with the B-lymphocyte depleting monoclonal antibody rituximab or with the anti-tumor necrosis factor-alpha agents etanercept and infliximab has shown promising results. We discuss the use of these and other biological agents targeting B lymphocytes, T-lymphocyte interaction with antigen-presenting cells, or cytokines in the future treatment of GO.