Biological evaluation of new percutaneous implanting materials
Tang, M.; Yang, X.; Wu, Y.; Cao, Y.; Luo, J.; Zhou, Y.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 25(1): 143-145
2008
ISSN/ISBN: 1001-5515 PMID: 18435277 Document Number: 617967
According to ISO 10993 standard series, the biological safety of surface modified pure titanium was studied as a percutaneous device by the test of cytotoxicity in vitro, as well as by the tests of irritation and sensitization. The result from the examination of cytotoxicity in vitro was negative, the skin irritation response was negligible, and the result of test on skin sensitization in guinea pigs was also negligible. So the surface modified pure titanium in this study can be safely used as percutaneous implanting materials.