Influence of hypothalamic stimulation on the development of status epilepticus in rats
Bilanishvili, I.; Chachua, T.; Koreli, A.; Khizanishvili, N.; Nanobashvili, Z.
Georgian Medical News 164: 57-61
2008
ISSN/ISBN: 1512-0112 PMID: 19075345 Document Number: 617685
The main objectives of the present study were to explore whether emotional behavior, elicited by stimulation of the dorso-medial hypothalamus, can influence seizure development during self-sustained status epilepticus (SSSE). The study was conducted on animal models. The results suggest that increased inhibition in the hippocampal neurons during dorsomedial hypothalamic stimulation may trigger the mechanisms preventing the epileptiform activity and that hippocampal theta rhythm is a physiological state, which opposes its involvement into seizures. It was concluded that activation of the dorsomedial hypothalamus, as well as emotional behavior (anxiety/fear) retard development of the seizures experimentally induced SSSE by limbic stimulation.