Place of inhibin B investigation in clinical andrological praxis
Porsová-Dutoit, I.
Vnitrni Lekarstvi 54(11): 1059-1062
2008
ISSN/ISBN: 0042-773X PMID: 19069679 Document Number: 617589
Inhibin B is a gonadal dimeric peptide, produced in men in testicular Sertolli cells. Inhibin B blood level knowledge can be a useful tool in the management of difficult diagnostic problems, such as ambiguous genitalia, the distinction between cryptorchidism and anorchidism and the hypogonadotrophic hypogonadism/delayed puberty differential diagnosis. Inhibin B measurements can help in gonadal dysgenesis evaluation, androgen insensitivity management and also in the diagnosis of some gonadal tumors. In adult men, inhibin B evaluation is helpful in the investigation of male infertility, especially in the judgment of the prognosis of testicular biopsy in in-vitro fertilization programs. Although commercial kits for inhibin B measurement are available at present, its evaluation is accessible in the Czech Republic for the time being in only very limited number of laboratory centers.