Normal pregnancy resulting from a non-pronuclear oocyte at the time of examination for fertilization
Burney, R.O.; Gebhardt, J.; Shu, Y.; Behr, B.; Westphal, L.M.
Clinical and Experimental Obstetrics and Gynecology 35(3): 170-171
2008
ISSN/ISBN: 0390-6663 PMID: 18754284 Document Number: 616928
To report the case of a patient undergoing in vitro fertilization (IVF) in which a non-pronuclear (0PN) oocyte resulted in a normal pregnancy. A 36-year-old woman underwent an IVF-embryo transfer treatment cycle. Four oocytes were retrieved for insemination by IVF. Examination for fertilization revealed two polypronuclearpolygynic and two non-pronuclear oocytes. The non-pronuclear oocytes were observed further for development. One embryo developed from the non-pronuclear cohort and was transferred at the 8-cell stage on day 3. Subsequently, a pregnancy developed, and resulted in the delivery of a healthy term infant. Non-pronuclear oocytes may represent a source of developmentally competent embryos, and further observation of this cohort should be considered, particularly in situations involving a low yield of oocytes at retrieval.