Neisseria meningitidis. The pathophysiological role of lipopolysaccharides in association with meningococcal disease and septic shock
Pedersen, M.Østergaard.; Pedersen, D.Sonne.; Pedersen, M.; Penkowa, M.
Ugeskrift for Laeger 170(6): 421-426
2008
ISSN/ISBN: 0041-5782 PMID: 18252172 Document Number: 616529
A major pro-inflammatory and toxic component of N. meningitidis is lipopolysaccharide (LPS). LPS contributes to severe symptoms of meningococcal disease, septic shock and severe coagulopathy, in part by increasing pro-inflammatory mechanisms and reactive oxygen species. Recent technologies have increased the likelihood of developing an anti-meningococcal immunization strategy based upon the virulence of LPS which may lead to a vaccination against this important pathogen including serogroup B disease. This review summarizes recent findings that may provide a safe, effective prophylaxis and therapy.