Analysis of dystrophin gene deletions in patients from the Mexican population with Duchenne/Becker muscular dystrophy
Coral-Vázquez, R.; Arenas, D.; Cisneros, B.; Peñaloza, L.; Kofman, S.; Salamanca, F.; Montañez, C.
Archives of Medical Research 24(1): 1-6
1993
ISSN/ISBN: 0188-4409 PMID: 8292871 Document Number: 6163
Forty unrelated Mexican patients with Duchenne/Becker muscular dystrophy were analyzed for intragenic DMD gene deletions, using the multiplex amplification of 15 deletion-prone exons described by Chamberlain et al. and Beggs et al. The percentage of deletions was 52.5%, and the majority of them (86.3%) were located at the hot spot deletion region which encompasses exons 44-55. This frequency is higher than that found in American and European populations. There were no correlations between deletion size, location and clinical severity.
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