Toll-like receptors, a new way of treatment?
Pedersen, C.V.B.ød.; Østergaard, L.J.; Mogensen, T.H.; Paludan, S.ør.R.; Bertelsen, L.S.
Ugeskrift for Laeger 169(23): 2193-2198
2007
ISSN/ISBN: 1603-6824 PMID: 17592684 Document Number: 614931
Toll-like receptors (TLRs) comprise a group of recently discovered receptors which are essential molecular structures in the activation of immunity. The discovery of TLRs has provided a substantial increase in the knowledge of immunologic aspects of disease pathology and is presently giving rise to new treatment strategies. This review summarizes the current knowledge on TLRs functioning in infections, their possible roles in inflammatory bowl disease and the pivotal role for TLRs in endotoxic shock, an area which is currently subject to development of a new farmakon.