Valve replacement for bacterial and fungal endocarditis. A comparative study
Utley, J.R.; Mills, J.; Hutchinson, J.C.; Edmunds, L.H.; Sanderson, R.G.; Roe, B.B.
Circulation 48(1): III42-III47
1973
ISSN/ISBN: 0009-7322 PMID: 4737233 Document Number: 61469
Of 143 patients treated for infective endocarditis, 28 had replacement of 1 or more cardiac valves within 6 months after diagnosis. All 6 patients with fungal endocarditis, caused by Candida krusei, C. parakrusei, C. guilliermondii or Torulopsis glabrata, required valve replacement and one died in hospital. Massive emboli or persistent mycotic septicaemia were the indications for valve replacement in patients with fungal endocarditis. Viable organisms were cultured from the excised valves in all patients in spite of preoperative amphotericin B for 30 to 140 days and negative blood cultures. Excision of the infected valve cured the infection in all patients.